sirtuin相关论文
许多神经系统疾病都会影响昼夜节律。尽管已知癫痫常伴睡眠障碍,但与癫痫昼夜节律紊乱相关的数据却很少。文章检验了Kcna1缺失小鼠......
Vascular hyporeactivity is one of the major causes responsible for refractory hypotension and associated mortality in va......
Background and Objective: Negative feedback is common in biological processes and can increase a systems stability to in......
We discovered in the current study that six side chain-to-side chain cyclic pentapeptides harboring a central Nε-dodecy......
In the current study,we discovered that several N-terminus-to-side chain cyclic tripeptides harboring the catalytic mech......
研究了低强度810 nm半导体激光（LIDL）对肿瘤坏死因子α(TNF-α)抑制的NIH3T3成纤维细胞时钟基因表达的调节作用。马血清休克2 h的细......
Sirtuin是Ⅲ类组蛋白去乙酰化酶。通过对组蛋白和非组蛋白的去乙酰化作用，Sirtuin蛋白家族成员可调控多种疾病的病理生理过程，如能量......
DKD是DM常见微血管并发症,因其高患病率和不良预后,逐渐成为DM和肾脏病领域的研究热点.去乙酰化酶Sirtuin家族与IR、炎症、氧化应......
14-Deoxygarcinol,a polyisoprenylated benzophenone from Garcinia cambogia,ameliorates inflammatory re
OBJECTIVE Interleukin(IL)-1β,one of the principal inflammatory cytokines mainly secreted by monocytes and macrophages,i......
Sirtuin是一类β-NAD+依赖的蛋白Nε-酰化赖氨酸去酰化酶,该酶存在范围十分广泛,包括细菌到人类的所有的生命体,是进化上相对保守......
由衰老引起的死亡是动物在资源有限的情况下发展的一种过程,其功能是限制个体的寿命以换取种群的生存。衰老的过程和生长发育的过......
,Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decr
Chronic alcohol intake decreases adiponectin and sirtuin 1 (SIRT1) expressions, both of which have been implicated in va......
How plant metabolic flux alters gene expression to optimize plant growth and response to stress remains largely unclear.......
SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zy
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
Sirtuin是一类作用于组蛋白的去乙酰化酶，Sirtuin-1（SIRT1）是哺乳动物中与沉默调控基因SIR2同源性最高的同系物。SIRT1的主要功能足调......
Insight into Reaction Mechanism of Sirtuins via Molecular Simulation and Density Functional Theory S
本文通过对荣华二采区10...
Sirtuin是Ⅲ类去乙酰化酶基因家族,可调节代谢、衰老、凋亡及炎症.已知Sirtuin调节剂有治疗或预防肥胖、肿瘤的发生、老化、心功能......
能量限制(caloric restriction)是延缓衰老的最为有效的手段,但在人类应用困难.能量限制拟似物可在不改变能量摄入的条件下,模拟能......
糖尿病心肌病是除外冠状动脉疾病或高血压等糖尿病继发性损害之外独立存在的特异性心肌损害,是糖尿病患者发展为心力衰竭的重要原......
Insight into Reaction Mechanism of Sirtuins via Molecular Simulation and Density Functional Theory S
With density functional theory(DFT) and molecular mechanics method, the catalytic mechanism of silent information regula......
背景卵泡是卵巢的基本结构及功能单位。女性出生时,双侧卵巢内储存大量处于休眠阶段的原始卵泡。进入青春期后,99%的原始卵泡发生......
Ischemia-reperfusion injury(IRI)remains an unresolved and complicated situation in clinical practice,especially in the c......
Sirtuin蛋白是一类称为依赖烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶,共有7个成员,均是潜在的疾病治疗靶点。然而,目前的荧光筛......
Sirtuin蛋白是一类称为依赖烟酰胺腺嘌呤二核苷酸（NAD）的组蛋白去乙酰化酶,共有7个成员,均是潜在的疾病治疗靶点。然而,目前的荧光筛......
Sirtuins蛋白家族是一类高度保守的组蛋白去乙酰化酶,在哺乳动物中有7个家族成员（Sirt1-7）.他们各自在肿瘤中发挥不同的作用,且有越......
衰老是机体退化时期功能下降及生理紊乱的综合表现。细胞自噬是依赖溶酶体对胞质蛋白和细胞器进行降解的一种途径,自噬可以维持细......
AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institut......
BACKGROUND Sirtuin 1(SIRT1)is a nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase that is involved i......
由衰老引起的死亡是动物在资源有限的情况下发展的一种过程,其功能是限制个体的寿命以换取种群的生存。衰老的过程和生长发育的过......
Berberine Ameliorates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Rats via Activation
This study aimed to verify the effects of berberine(BBR)on the fat metabolism proteins involved in the sirtuin 3(SIRT3)/......
目的观察氯化钴（CoCl2）对耳蜗毛细胞和神经节细胞的损伤模式并探讨Sirtuin 1（SIRT1）在耳蜗缺氧过程中的作用。方法采用CoCl2作用于离体......
由衰老引起的死亡是动物在资源有限的情况下发展的一种过程,其功能是限制个体的寿命以换取种群的生存。衰老的过程和生长发育的过......
目的：研究蛋白酶Sirtuin 1在牙周膜干细胞骨向分化中的作用。方法：筛选人因正畸而拔除的前磨牙,获取牙周膜组织做细胞培养,并行牙周......
摘 要：Sirtuins(SIRTs)是依赖于烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleotide，NAD )的去乙酰化酶。除了对染色质组......
Effects of acute doxorubicin treatment on hepatic proteome lysine acetylation status and the apoptot
AIM: To determine if doxorubicin(Dox) alters hepatic proteome acetylation status and if acetylation status was associate......
AIM： To investigate the therapeutic effects of luteinagainst non-alcoholic fatty liver disease （NAFLD） andthe related under......
AIM To investigate a possible association betweenlosartan and sirtuin 1 （SIRT1） in reduced-size orthotopicliver transplant......
With density functional theory(DFT) and molecular mechanics method, the catalytic mechanism of silent information regula......
Melatonin modifies SOX2~+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-
Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem ......
Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, co
Obesity, especially at mid-life, is a major risk factor for atherosclerosis, insulin resistance and the metabolic syndro......
The acceleration of aging and Alzheimer’s disease through the biological mechanisms behind obesity a
The incidence of diabetes is predicted to increase to 21% by 2050. Currently, one third of US adults are obese and over ......
酒精性肝病(alcoholic liver diseases,ALD)包括一系列临床疾病和肝组织病理的变化,包括酒精性脂肪肝(alcoholic fatty liver,AFL)......
目的:1.构建及验证模拟人类常见饮酒模式的新型酒精性肾损伤小鼠模型。2.观察sirtuin蛋白家族在酒精性肾损伤模型中的表达,重点探......
背景:氧化应激严重制约着干细胞治疗效能,而去乙酰化酶Sirtuin(SIRT)家族作为细胞内重要的抗氧化酶在调节干细胞结构和功能完整性......
Sirtuins是一类能够依赖β-烟酰胺腺嘌呤二核苷酸(β-NAD+)催化Nε-酰化-赖氨酸去酰化反应的酶家族,与翻译后修饰―蛋白赖氨酸酰化......
Sirtuin家族的酶能够催化无论组蛋白还是非组蛋白底物上的酰化赖氨酸侧链的去酰化反应。细菌和古生菌通常包含一至两个sirtuins,而......
近20年来,我国居民的生活水平显著提高,饮食方式的变化使得城乡居民的热量摄入已超标准。过度摄入热量会使体内细胞耗氧增加,细胞......
目的探讨Sirtuin5(SIRT5)对高糖环境下Lovo细胞增殖、凋亡及迁移的影响及可能机制。方法高糖培养基(葡萄糖含量4500 mg/L)及普通培......
